DEVELOPMENT: Import Controls

Agglomeration and economic development: Import substitution vs trade liberalisation

This paper analyses a model of economic development in which international differences in industrial structure and income are caused by the agglomeration of industry in a subset of countries. Economic development may not be a gradual process of convergence by all countries, but instead involve countries moving sequentially from the group of poor countries to the group of rich countries. The rol...

FDA import automation: Serious management and systems development problems persist

The SOS section is devoted to success and failure pattems with information technology. Authors like to report successes; it is much harder to find examples of problems and failures to discuss in these pages. The U.S. General Accounting Office is an organization devoted to the analysis of government activities. Its tone is critical, but many of its supporters say such an approach is necessary to...

Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.

Accurate cellular localization plays a crucial role in the effective function of most signaling proteins, and nuclear trafficking is central to the function of transcription factors. IFN regulatory factor (IRF)3 is a master transcription factor responsible for the induction of type I IFN, which plays a crucial role in host antiviral innate immune responses. However, the mechanisms for control a...

Activity of IFN Regulatory Factor 3 Controls Nuclear Import and DNA - Binding Bipartite Nuclear Localization Signal

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

The nuclear import of the nuclear factor of activated T cells (NFAT)-family transcription factors is initiated by the protein phosphatase calcineurin. Here we identify a regulatory region of NFAT1, N terminal to the DNA-binding domain, that controls nuclear import of NFAT1. The regulatory region of NFAT1 binds directly to calcineurin, is a substrate for calcineurin in vitro, and shows regulated...